場所：東大本郷キャンパス 医学部教育研究棟13階 第6セミナー室 ※対面のみ
講演者： Shelley Halpain 氏(カリフォルニア大/Stanford Consortium for Regenerative Medicine)
タイトル：Actin in Self Defense: Neuronal Pro-survival Responses to Ischemic Stress
The brain is well known to exhibit a high metabolic demand due to both active and passive neural processes that support network signaling, the main function of the nervous system. Little is known, however, in how neuronal energy consumption occurs at the subcellular level. Our lab is applying its expertise in subcellular imaging to investigate energy consumption within neuronal dendrites and dendritic spines. We are also investigating how neurons respond when there is a sudden loss of energy availability, as during acute injuries like hypoxia, stroke or traumatic brain injury (TBI). Like most cells in the body, neurons organize protective responses in an attempt to counteract these dangerous conditions. We are characterizing the pro-survival responses of neurons, including how reorganization of the actin cytoskeleton regulates such neuroprotection.
Reference: Calabrese, B., Jones, S.L., Shiraishi-Yamaguchi, Y., Manor, U., Svitkina, T.M., Higgs, H.N., Shih, A.Y., and Halpain, S. (2022) INF2-mediated actin filament reorganization confers intrinsic resilience to ischemic neuronal injury. Nature Communications. Oct 13, 13 (1): 6037