講演者：Deepak Bhat氏 (OIST)
タイトル：Dynamics of replisome along bacterial genome
Replisomes are multi-protein complexes that replicate
genomes with remarkable speed and accuracy. In bacteria, two replisomes
initiate replication at a well-defined origin site on the circular
genome, progress in opposite directions, and complete replication upon
encountering each other in a terminal region. Precise features of
replisome dynamics, such as whether their speed is approximately
constant or varies along the genome, are important to determine the
location of their encounter point and the distribution of replication
errors on the genome. But this detailed information is hard to obtain.
We developed a mathematical model to infer the replisome dynamics from
the DNA abundance in a growing bacterial population. I will discuss our
findings in detail in this seminar.