第52回IPB セミナー

[セミナー］第52回IPB セミナーを開催します。
日時：2024年5月29日(水)10:30
場所：東大(本郷キャンパス)理学部1号館233室&Zoom
講演者：Guillaume Duménil 氏(パスツール研究所)
title：The mechanics of bacterial infections, the case of Neisseria meningitidis vascular colonization
https://lab.kaztake.org/data/seminar/html/index-j.html

Abstract:
Bacteria encounter and exert mechanical forces, although this physical dimension has been less studied compared to their eukaryotic cell counterparts. Neisseria meningitidis, or meningococcus, is a bacterial pathogen responsible for human septicaemia and meningitis. Infection caused by this bacterium and its interaction with the human host is largely determined by mechanical forces at several levels. Bacterial adhesion to the endothelium is mediated by a filamentous structure called the type IV pilus, which can generate piconewton traction forces. Bacteria form aggregates inside the vessel lumen that have viscous fluid properties. Once the lumen is filled, the bacteria proliferate in a spatially confined environment. The biological and mechanical processes that occur during these sequential host-pathogen interactions will be described and their implications during the infection process discussed.