[セミナー］第41回IPB セミナーを下記の通り開催します。

[セミナー］第41回IPB セミナーを下記の通り開催します。
日時：2023年7月11日（火）17:00-18:00
場所：東大本郷キャンパス医学部教育研究棟13階第６セミナー室
講演者：Anna Akhmanova氏 (ユトレヒト大)
タイトル：Control of microtubule organization and dynamics

Abstract: Microtubules are dynamic cytoskeletal filaments that control different aspects of cell architecture. Microtubules are intrinsically asymmetric polymers, with fast-growing plus ends, which in cells serve as major sites of microtubule assembly and disassembly, and slow-growing minus ends, which are often stabilized and attached to different cellular structures. In my lab, we use in vitro assays combined with single molecule imaging to dissect how the proteins that bind to microtubule plus- and minus ends control microtubule nucleation and growth and thus regulate formation of dynamic microtubule networks or the stable cores of centrosomes and cilia. In parallel, we employ live cell imaging to study how microtubules contribute to cell polarity, migration, division and differentiation. In my seminar, I will discuss the interplay between microtubule nucleation by gamma-tubulin ring complex, minus end stabilization by CAMSAP family proteins and microtubule severing by katanin. I will also describe the characterization of an optogenetic tool for local microtubule disassembly and its application to studying cell architecture,

[Career]
1992-1996: PhD student, Department of Genetics, University of Nijmegen, The Netherlands
1996-1997: Postdoc, Department of Microbiology, University of Nijmegen, The Netherlands
1997-2001: Postdoc, Department of Cell Biology, Erasmus MC Rotterdam, The Netherlands
2002-2008: Assistant Professor, Department of Cell Biology, Erasmus MC Rotterdam, The
Netherlands
2008-2010: Associate Professor, Department of Cell Biology, Erasmus MC Rotterdam, The
Netherlands
2011-present: Full professor, Department of Biology, Faculty of Science, Utrecht University, The Netherlands